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KMID : 1141520220370040587
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Endocrinology and Metabolism
2022 Volume.37 No. 4 p.587 ~ p.598
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Long-Term Outcomes of Congenital Adrenal Hyperplasia
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Nordenstrom Anna
Lajic Svetlana
Falhammar Henrik
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Abstract
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A plethora of negative long-term outcomes have been associated with congenital adrenal hyperplasia (CAH). The causes are multiple and involve supra-physiological gluco- and mineralocorticoid replacement, excess adrenal androgens both intrauterine and postnatal, elevated steroid precursor and adrenocorticotropic hormone levels, living with a congenital condition as well as the proximity of the cytochrome P450 family 21 subfamily A member 2 (CYP21A2) gene to other genes. This review aims to discuss the different long-term outcomes of CAH.
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KEYWORD
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Cardiovascular diseases, Bone fracture, Mental disorders, Neoplasms, Mortality, Fertility
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